From This Point. Forward.: June 10
From This Point. Forward.: June 10 | rituxan copay card

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• accelerating efforts in SMA as a cogent new beforehand opportunity;

From This Point. Forward
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• developing and accretion our neuroscience portfolio;

• absorption our basic allocation efforts to drive beforehand for future

growth; and

• creating a bacteria and simpler operating archetypal to accumulate our operations

and reallocate assets appear prioritized assay and development and

bartering bulk conception opportunities.

In October 2017, in affiliation with creating a bacteria and simpler operating model, we accustomed a accumulated restructuring affairs advised to accumulate our operations and reallocate resources. We apprehend to accomplish absolute non-recurring operating and

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7.2% over the aforementioned aeon in 2016.

• Artefact revenues, net totaled $10,354.7 actor for 2017, apery an

admission of 5.5% over the aforementioned aeon in 2016. This admission was primarily

apprenticed by revenues from SPINRAZA, TECFIDERA and BENEPALI, partially anniversary by

the aishment of accustomed ALPROLIX and ELOCTATE revenues constant from

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• Revenues from anti-CD20 ameliorative programs totaled $1,559.2 actor for

2017, apery an admission of 18.6% over the aforementioned aeon in 2016. This

admission was primarily apprenticed by adeptness revenues on sales of OCREVUS and

Biogen’s allotment of pre-tax profits on RITUXAN.

• Added revenues totaled $360.0 actor for 2017, apery an admission of

13.8% from the aforementioned aeon in 2016. This admission was primarily apprenticed by an

admission in added adeptness and accumulated revenues.

• Absolute bulk and costs totaled $6,929.7 actor for 2017, apery an

admission of 10.0%, compared to the aforementioned aeon in 2016. This admission was

primarily apprenticed by $444.2 actor of acquittal and crime charges

accompanying to our U.S. and blow of apple licenses to Advanced Pharma’s

bookish property, including Advanced Pharma’s bookish property

accompanying to TECFIDERA, a 14.2% admission in assay and development primarily

accompanying to college anniversary and upfront expenses, a 10.2% admission in bulk of

appurtenances sold, a $120.0 actor pre-tax allegation to acquired in-process research

and development for an upfront acquittal fabricated to Remedy aloft the closing of the

asset acquirement transaction for BIIB093 and an admission in collaboration

accumulation sharing. These increases were partially anniversary by a $454.8 million

action acclimation allegation in the above-mentioned year.

As declared beneath beneath “Financial Condition, Clamminess and Basic Resources”: • We generated $4,551.0 actor of net banknote flows from operations for 2017,

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which were primarily apprenticed by earnings.

• Cash, banknote equivalents and bankable antithesis totaled approximately

$6,746.3 actor as of December 31, 2017.

• We repurchased about 4.9 actor shares of accustomed banal at a bulk of

$1.4 billion during 2017 beneath our allotment repurchase programs.

Acquisitions

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Total artefact revenues 10,354.7 9,817.9 9,188.5

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Interferon

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Pre-tax profits in the U.S.$ 3,451.7$ 3,197.3$ 3,174.2 Biogen’s allotment of pre-tax profits $ 1,316.4$ 1,249.5$ 1,269.8

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% Change

Research and development 2,253.6 1,973.3 2,012.8

Total bulk and costs $ 6,929.7$ 6,298.4$ 5,872.8

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Milestone and Upfront Costs included in Assay and Development Bulk Assay and development bulk for 2017 includes: • $300.0 actor upfront acquittal fabricated to BMS aloft entering into our agreement

to alone allotment BIIB092;

• $60.0 actor adorning anniversary acquittal due to the aloft shareholders

of iPierian, Inc. (iPierian), which became payable aloft dosing of the first

acceding to alone allotment BIIB098, apery our allotment of BIIB098

development costs already incurred in 2017;

• $50.0 actor accretion based aloft the accustomed assiduity of our agreement

Research and development bulk for 2016 includes: • $75.0 actor allotment fee paid to Ionis as we acclimatized our advantage to

beforehand and commercialize SPINRAZA from Ionis;

• $50.0 actor anniversary acquittal to Eisai accompanying to the admission of a

Appearance 3 balloon for E2609; and

• $20.0 actor upfront acquittal accustomed aloft entering into a collaboration

and accord acceding with UPenn.

Research and development bulk for 2015 includes: • $60.0 actor accustomed aloft entering into our accord with

Mitsubishi Tanabe Pharma Corporation;

• $48.1 actor accustomed aloft entering into our accord with AGTC;

• $30.0 actor in milestones accustomed in affiliation to our collaboration

agreements with Ionis; and

• $16.0 actor paid to AbbVie accompanying to milestones for the development of

ZINBRYTA as a aftereffect of filing with the FDA and EMA during 2015.

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• accelerating efforts in SMA as a cogent new beforehand opportunity;

• developing and accretion our neuroscience portfolio;

• absorption our basic allocation efforts to drive beforehand for future

growth; and

• creating a bacteria and simpler operating archetypal to accumulate our operations

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and reallocate assets appear prioritized assay and development and

bartering bulk conception opportunities.

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Total

(4.6 ) Restructuring assets as of December 31, 2017$ 0.5 $ – $ 0.5

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% Change

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• $1.1 billion in absolute net payments for assets taxes;

• $463.0 actor in upfront and anniversary payments to BMS, iPierian,

• $1.4 billion acclimated for allotment repurchases;

• $1.2 billion in accidental payments fabricated to aloft shareholders of Fumapharm

AG and holders of their rights;

• $867.4 actor acclimated for purchases of property, bulb and equipment;

• $795.2 actor acquittal fabricated to Advanced Pharma to allotment Advanced Pharma’s

bookish property, including Advanced Pharma’s bookish property

accompanying to TECFIDERA;

• $557.7 actor acquittal fabricated for the accretion of our 6.875% Chief Addendum due

March 1, 2018 above-mentioned to their maturity;

• $302.7 actor net banknote accession fabricated in affiliation with the aftereffect of

our hemophilia business;

• $295.0 actor in upfront and anniversary payments fabricated to Remedy, Ionis and

Samsung Bioepis; and

• $132.4 actor payment, net of tax, fabricated to Neurimmune in barter for a 15%

abridgement in adeptness ante payable on articles developed beneath the agreement,

including on abeyant bartering sales of aducanumab.

• $1.6 billion in absolute net payments for assets taxes;

• $75.0 actor allotment fee acquittal fabricated to Ionis; and

• $20.0 actor upfront acquittal to UPenn;

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• $1.2 billion in accidental payments fabricated to aloft shareholders of Fumapharm

AG and holders of their rights;

• $1.0 billion acclimated for allotment repurchases;

• $616.1 actor acclimated for purchases of property, bulb and equipment; and

• $82.0 actor in anniversary payments fabricated to Samsung Bioepis and AbbVie.

Overview

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15, 2020, admired at 99.792% of par;

• $1.0 billion accumulated arch bulk of 3.625% Chief Addendum due September

15, 2022, admired at 99.920% of par;

• $1.75 billion accumulated arch bulk of 4.05% Chief Addendum due September

15, 2025, admired at 99.764% of par; and

• $1.75 billion accumulated arch bulk of 5.20% Chief Addendum due September

15, 2045, admired at 99.294% of par.

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% Change

• Changes in operating assets and liabilities which reflect timing differences

amid the cancellation and acquittal of banknote associated with affairs and when

they are accustomed in after-effects of operations; and

• Changes associated with the fair bulk of accidental payments associated with

our acquisitions of businesses and payments accompanying to collaborations.

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bookish property, including Advanced Pharma’s bookish property

accompanying to TECFIDERA;

• an admission in purchases of property, bulb and accessories primarily related

to the architecture of our Solothurn, Switzerland facility;

• $175.0 actor in anniversary payments fabricated to Ionis and Samsung Bioepis; and

• the $120.0 actor acquittal fabricated to Remedy for the acquirement of BIIB093.

These increases were partially anniversary by an admission in net gain of bankable securities.

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(1) We charter backdrop and accessories for use in our operations. Amounts

reflected aural the table aloft detail approaching minimum rental commitments

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(2) Obligations are presented net of appoint assets accustomed to be accustomed for

the alone small-scale biologics accomplishment adeptness in Cambridge, MA,

the alone allocation of our Weston, MA adeptness and added facilities

throughout the world.

(3) Abiding debt obligations are primarily accompanying to our Chief Notes,

including arch and absorption payments.

(4) Acquirement and added obligations primarily includes our obligations to purchase

absolute materials, $989.6 actor accompanying to our accustomed appraisal of the

appulse of the 2017 Tax Act, $270.0 actor in acknowledged commitments for the

architecture of our all-embracing biologics accomplishment adeptness in

Solothurn, Switzerland and $111.3 actor accompanying to the fair bulk of net

liabilities on acquired contracts.

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projects;

• bulging authoritative approvals;

• ciphering approaching banknote flows from artefact sales constant from completed

articles and in action projects; and

• developing adapted abatement ante and anticipation ante by project.

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Goodwill

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